扑炎痛尿药动力学测定

A study on the pharmacokinetics of benorylate in urine

本文用分光光度法测定扑炎痛的尿药动力学参数并与扑热息痛比较，二者的Ｘｕ￣１２、Ｘｕ￣２４、Ｋ、Ｔ＿（１／２）有明显差异（Ｐ＜０．０５），扑炎痛约４ｈ达尿药高峰，２４ｈ排出６０～７０％，４８ｈ排出７５～８５％。同服酸碱性药物时动力学参数无明显影响（Ｐ＞０．０１）。

A comparative pharmacokinetics between Benorylate and Paracetamol were studied in urine of 6 normal volunteers.Thepharmacokinetic parameter Xu￣12,Xu￣24,Ke,T_(1/2)of the two drugs are different (P<0.05).After 4hr Benorylate reached itspeak in urine. It was excreted in urine 60～70%and 75～85%after 24 and 48hr respectively. There is no difference in theadministration of Benorylate with other acidic or basic drugs(P<0.01).