芦丁共沉淀物的研究

Study on co-precipitates of rutin

将难溶性药物芦丁与亲水性载体ＰＶＰ制备成共沉淀物，实验研究表明，ＰＶＰ共沉淀物能显著增加芦丁的溶解度和溶出速率（Ｐ＜０．０１），而芦丁与ＰＶＰ的机械混合物与纯药的溶出速率无显著性差异（Ｐ＞０．０５）。

Since rutin exhibits a very low water solubility and bioavailablity, a co-precipitate of the drug was prepared from PVPwhich are water-soluble carriers.The experimental results in vital showed that the dissolution rate and solubility of the drug-PVP co-precipitates were increased significantly,but the dissolution rate of the relative mechanical mixture was increased in-sinificantly.