小半夏汤不同剂型药效学比较研究

A Comparison Study on Pharmacodynancics of Different Forms of Xiaobanxia Decoction

目的:比较仲景小半夏汤中原生药材制成的微粉中药与传统煎剂的药效。方法:用2%硫酸铜制备家鸽呕吐模型,用顺铂制备小鼠胃动素;随机分为模型组,小半夏汤煎剂高、低剂量组,小半夏汤粉剂高、低剂量组,胃复安阳性对照组;观察小半夏汤止吐效果及对胃动素影响情况,并比较小半夏汤煎剂和粉剂对正常小鼠的肠推进影响。结果:小半夏汤煎剂、粉剂均对家鸽呕吐模型有显著止吐作用,并能显著降低血液中胃动素(MTL)水平;两种剂型均可显著降低正常小鼠小肠推进速度。结论:小半夏汤粉剂疗效优于传统煎剂,但统计学意义不明显。

Objective: To study the potency comparison between grounded powder from the decoction and traditional decocted abstract. Methods: Domestic pigeon vomiting models were made with 2% copper sulphate and motilin was made with cisplatin. The subjects were randomly divided into model group, Xiaoban xia Decoction high dose group, Xiaoban xia Decoction low dose group. Xiaoban xia miropowder high dose group, Xiaoban xia miropowder low dose group and the control group of maxolon positive. An observation was made on its antiemetic effect and influence on motilin. Meanwhile, the influence of Xiaobanxia Decoction on the intestinal promotion was compared with that of Xiaobanxia miropowder on the intestinal promotion. Results: 1. After the application of drugs, Xiaobanxia Decoction group and Xiaobanxia miropowder group had distinctive influence on domestic pigeon vomiting model and motilin could be lowered dramatically. 2. The speed of rat's intestinal promotion was markedly lowered. Conclusion: The curative effect of Xiaobanxia miropowder is better than that of Xiaobanxia Decoction, but it isn't significant in statistics.