宫血立停冲剂止血作用的临床研究

A Clinical Research into the Hemostatic Effect of Gongxue Liting Powder

目的:观察宫血立停冲剂止血作用的临床疗效及其机理。方法:观察无排卵功血出血期患者59例,随机分为治疗组(宫血立停冲剂)30例,对照组(宫血宁胶囊)29例,用单盲法进行疗效观察。结果:宫血立停冲剂治疗无排卵功血止血疗效显著。治疗组治疗后平均血红蛋白浓度(MCHC)、纤维蛋白原(FIB)、6-酮-前列腺素PGF1α(6-K-PGF1α)、凝血三项(PT、APTT、TT)比治疗前降低(P<0.05)。红细胞体积分布幅度-变异系数(RDW-CV)、血小板体积分布幅度(PDW)、平均血小板容积(MPV)、血栓素B2(TXB2)比治疗前升高(P<0.05)。结论:宫血立停冲剂治疗无排卵功血止血疗效显著,其止血机理可能为:提高血小板的聚集粘附能力,改变患者的凝血机制,使止血成为可能;调节前列腺素类物质的释放从而加强子宫收缩,促进纤溶活性,使坏死子宫内膜脱落排出止血。

Objective: to obsever the curative effect and mechanism of Gongxue Liting Powder. Methods: 59 cases with anobvulatory metropathia hemorrhagica were divided into the treatment group (30 cases) with Gongxue Liting Powder, the control group (29 cases) with Gongxuening Capsule. An obserbvation was made on the treatment with the single blind method. Results: The powder was markedly effective in treating the treatment group. MCHC, FIB, PGF_ 1α(6-K-PGF_ 1α). PT, APTT and TT lowered after treatment (P<0.05), RDW-CV, PDW, MPV and B_2 (TXB_2) increased (P<0.05). Conclusion: The powder is distinctively effective in the trearment of the cuse. Its hemostatic mechanism can be as following: increasing platelet adhesiveness, improving blood coagulation mechanism, regulating the release of prostaglandin to contract uterine, improving fibrinolytic function to shed necrotic endometrium.