惊恐障碍患者听觉诱发电位的动态检测及临床意义

Auditory evoked potential in panic disorder :A follow-up study

目的探讨惊恐障碍(PD)患者听觉诱发电位(AEP)的特点。方法应用丹麦Keypoint肌电/诱发电位仪,记录29例PD患者(PD组)和29名健康人(NC组)的AEP。PD组患者服用5-羟色胺再摄取抑制剂4周、12周、24周时予以复查。结果(1)治疗前,PD组AEP-N2潜伏期[(237.88±16.64)ms]长于NC组[(223.48±18.27)ms,P<0.05],N1-P2波幅[(4.29±2.02)μV]低于NC组[(8.39±2.49)μV,P<0.01],P2-N2波幅[(4.05±1.57)μV]低于NC组[(7.65±3.54)μV,P<0.01]。(2)治疗后,PD组患者随情绪和行为改善,HAMA分数降低,AEP-N2潜伏期逐渐缩短,至治疗24周时与治疗前差异有显著性[治疗前(237.88±16.64)μV,治疗24周时(210.52±26.58)μV,P<0.05],余各项指标差异无显著性。结论PD患者AEP变化与临床症状有关,且滞后于临床症状的改善。

ObjectiveTo investigate the characteristics and clinical significance of auditory evoked potential (AEP) in panic disorder (PD). MethodsAEP were recorded from 29 PD patients using a keypoint instrument, and compared with that of 29 normal controls (NC).PD patients were followed up with the same markers after SSRI treatment for 4 weeks, 12 weeks and 24 weeks.Results(1)Compared with NC, PD patients showed delayed N_ 2 latency[(237.88±16.64)ms vs (223.48±18.27)ms, P <0.05] ,decreased N_ 1- P_ 2 amplitude [( 4.29 ±2.02)μV vs.(8.39±2.49)μV, P <0.01]and P_ 2- N_ 2 amplitude [(4.05±1.57)μV vs.(7.65 ±3.54 )μV, P <0.01].(2)With the decreasing of HAMA scores, after 24 weeks N_ 2 latencies of PD patients obviously shortened [(210.52±26.58)ms vs.(237.88±16.64)ms, P <0.01].N_ 1 P_ 2 and P_ 2 N_ 2 amplitudes showed an increasing tendency , but there weren't statistic differences. ConclusionThe AEP variation in PD might correlate with the symptoms status of PD and be later than the improvement of the clinical symptoms. It deserves more investigation.