异丙肾上腺素透皮控释贴剂的研究

Study on controlled release transdermal therapeutic system of isoprenaline

本文将异丙肾上腺素研制成胶粘剂层扩散控制型透皮贴膜剂。建立二阶导数紫外分光光度法，考察了药物贴片的体外释放速率及经离体鼠皮的渗透速率。结果表明由胶粘剂层控制的贴片对药物有良好的控制作用，药物以零级动力学方式释放和渗过皮肤。体外释药速率及离体皮肤渗透速率分别为１９．７９μｇ／（ｃｍ￣２·ｈ）和１８．８９μｇ／（ｃｍ￣２·ｈ），且可持续稳态释放２４ｈ以上。

A controlled release transdermaal therapeutic system of isoprenaline(kq-TTS )was developed for the treatment ofbronchial asthma. The release rate and skin permation rate of isoprnaline from Isop-TTS in vitro were studied using the sec-ond-order derivative UV spectophotometry. results suggested that a controlled release of isoprenaline with a release rate of zero-order during 24 hours be obtained.