盐酸苯环壬酯对小鼠的围产期毒性试验研究

Experimental study of perinatal and postnatal toxicity of phencynonate hydrochloride in mice

盐酸苯环壬酯分成２．５、１２．５和６２．５ｐｐｍ３个浓度组，溶于自来水中，供孕鼠从妊娠ｄ１５开始至断乳时饮用。结果显示，在相当于人临床用量１５～７５倍剂量范围内，该药对小鼠胚胎后期生长发育、母鼠分娩、哺乳及新生小鼠神经行为发育无明显影响。６２．５ｐｐｍ组孕鼠给药期间体重增长抑制，死产仔鼠数增多，雄性仔鼠肝脏重量增加，表现出一定的母体毒性和发育毒性。

Phencynonate hydrochloride was administered in drinking water to pregnant mice during the last quarter of pregnancy andthrough lactation to weaning at dose levels of 2.5,12.5 and 62.5ppm. Weights, food intake and toxic signs were recorded atregular intervals and pregnancy outcome evaluated. Pups were assessed for growth ,neurobehavioral development and toxicsigns prior to weaning. Offspring were also evaluated with a multi-item neurobehavioral test battery.Late fetal development,labor ,delivery ,lactation , neonatal viability ,and growth were not affected at 2.5ppm and 12.5ppm. The suppression of ma-ternal body weigt gains was shown during the administration peried at 62.5ppm. Liver weights in male f_1 mice and the per-centage of late dead fetuses were in creased at the same dose level.These results show that maternal dietary exposure to phen-cyn onate hydrochloride during gestation and lactation which produce maternal toxicity can result in development toxicity inmice at 62.5ppm.