舌下片与硝苯地平片血药浓度测定与药物动力学研究

Blood concentration determination and clinical Pharmacokinetic studies on oral nifedipine sublingual and conventional tablet

本文用毛细管气相色谱法（ＧＣ─ＥＣＤ）测定了血清中硝苯地平浓度。并对９名受试者服２０ｍｇ硝苯地平舌下片和国产普通片的药物动力学进行了比较研究。舌下片、普通片主要动力学参数为：Ｋａ（ｈ￣－１）＝７．５５、２．０８；ｋｅ（ｈ￣－１）＝０．３１、０．２１；Ｖ／Ｆ［ｍｇ／（ｎｇ／ｍｌ）］＝０．１６、０．２９；Ｔ＿ｐｅａｋ（ｈ）＝１．６８、２．２７；Ｃ＿ｍａｘ（ｎｇ／ｍｌ）＝１００．０５、５８．０８。结果舌下片吸收快、峰浓度高、起效时间明显提前。

Serum nifedipine concentrations were determined by GC─ECD. The pharmacokinetic comparison wes made between oralnifedipine sublingual and conventional tablet at a dose of 20mg in 9 volunteers.The pharmacokinetic parameters of sublingualand conventional tablet are:Ka=7.55, 2.08h￣-1; Ke=0.31h￣-1,0.21; V/F=0.16, 29ml/mg; T_peak=1.68, 2. 27h; Cmax= 100. 05, 58. 08ng/ml respectively. The results showed that onset for sublingual tablet had a more rapid onset than con─ventional, the peak concentration of subligual higher than conventional tablet.