安宫牛黄丸佐治新生儿中重度缺氧缺血性脑病疗效观察

Effect of Angong Niuhuang Pill as an Adjuvant Treatment on Moderate or Severe Neonatal Hypoxic-ischemic Encephalopathy

目的观察安宫牛黄丸佐治新生儿中、重度缺氧缺血性脑病疗效及安全性。方法治疗组(58例)在对照组(39例)常规治疗基础上加用安宫牛黄丸治疗,观察比较两组相应指标的变化。结果治疗组在意识、肌张力、原始反射恢复、惊厥消失等方面疗效均优于对照组(P<0.01)。结论安宫牛黄丸可促进新生儿缺氧缺血性脑病病情的恢复,减少后遗症,安全性好。

ObjectiveTo evaluate the clinical efficacy and safety of Angong Niuhuang pill (ANP) as an adjuvant treatment on moderate or severe neonatal hypoxic-ischemic encephalopathy (NHIE). MethodsThirty-nine neonates with NHIE in the control group were treated with conventional treatment, and 58 in the treated group were administered orally ANP additionally, and relative indexes were observed. ResultsThe improvement of aspects such as recovery of consciousness, muscular tension, and primitive reflex and disappearance of convulsion, in the treated group was better than that in the control group (P<0.01). ConclusionANP as an adjuvant treatment has a definite effect on NHIE, it can promote the recovery of patients, decrease the occurrence of sequelae and with high safety, therefore, is a drug feasible for clinical application.