胃癌患者手术前后T淋巴细胞嗜银蛋白含量变化及参芪扶正注射液对其影响

Effect of Shenqi Fuzheng Injection on Pre/post-Operational Change of Argyrophilic-nucleolar Organizer Regions in Peripheral T-Lymphocyte in Patients with Gastric Carcinoma

目的探讨胃癌患者外周血T淋巴细胞嗜银蛋白含量在手术前后的变化以及免疫调节剂参芪扶正注射液(简称参芪液)对其的影响。方法根据85例患者是否行根治术分为两组,每组再根据是否静脉滴注参芪液随机分两组,分别对其手术前后和12名健康人进行外周血T淋巴细胞嗜银蛋白含量的检测。结果胃癌患者T淋巴细胞嗜银蛋白含量较健康人显著降低(P<0.01);根治组(64例)术后T淋巴细胞嗜银蛋白含量较术前明显升高(P<0.05或P<0.01),应用参芪液治疗的患者(36例)升高更加显著(P<0.05);非根治组(21例)手术前后无明显变化,但应用参芪液治疗的患者(13例)升高显著(P<0.05)。结论胃癌患者T淋巴细胞免疫功能低下,在其手术后辅助性应用参芪液可明显改善其细胞免疫功能。

ObjectiveTo investigate the pre-post operational change of argyrophilic -nucleolar organizer regions (Ag-NORs) in peripheral T-lymphocyte of patients with gastric carcinoma (GC), and to explore the effect of Shenqi Fuzheng injection(SFI) on it. MethodsEighty five patients were divided into two groups according to the operation performed was radical or non-radical, and the two groups were subdivided into two by additional intravenous dripping of SFI was given to them or not. The content of Ag-NORs in peripheral T-lymphocyte in all patients before and after operation as well as in 12 healthy subjects was determined. ResultsContent of Ag-NORs in GC patients was significantly lower than that in the healthy subject (P<0.01), which significantly increased after patients underwent radical operation (P<0.01 or P<0.05), especially in those treated with SFI (P<0.01).While in patients underwent non-radical operation but not treated with SFI, it showed insignificant change after operation, however it did significantly increase in those treated with SFI (P<0.05). ConclusionThe immune function of T lymphocyte was low in patients with gastric carcinoma, post-operational adjuvant treatment of SFI can significantly improve the cellular immunity of patients.