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副癌性亚急性小脑变性4例追踪观察报告 被引量:1

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摘要 副癌性小脑变性(PCD)又称副肿瘤性小脑变性,是由恶性肿瘤引起的一种神经系统综合征.Brouwen首先作了描述,但到1938年才认识到与肿瘤的关系[1].主要表现为亚急性小脑性共济失调,可伴眼球震颤、复视及构音困难等.多数病人脑脊液有淋巴细胞和蛋白增高,头颅CT或MRI早期正常,后期显示弥漫性小脑萎缩,相关肿瘤主要是肺癌、卵巢癌、乳腺癌等.发病机制尚未阐明,可能与肿瘤抗原引起的自体免疫反应有关[2].由于PCD可出现于癌肿诊断前数月甚至数年,故易误诊.现报告本院收治的4例.
出处 《浙江临床医学》 2005年第7期709-709,共1页 Zhejiang Clinical Medical Journal
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  • 1Setareh SL, Joost, Bertie L, et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain,2003,126(Part 6): 1409 ~ 1418.
  • 2Widdess - Walsh P, Tavee JO, Schuele S, et al. Response to intravenous immunoglobulin in anti - Yo associated paraneoplastic cerebellar degeneration:case report and review of the literature. J Neurooncol 2003,63(2):187.

同被引文献12

  • 1赵勇,张文乾,王先梅.以神经副癌综合征为首发表现的肺癌误诊分析[J].实用肿瘤杂志,2005,20(1):70-72. 被引量:4
  • 2史玉泉.实用神经病学[M].上海:上海科学技术出版社,1994.1076.
  • 3Storstein A, Knudsen A, Vedeler CA. Proteasome antibodies in paraneoplastic cerebellar degeneration [ J ]. Journal of Neuroimmunology,2005,165(1-2) :172 - 178.
  • 4Graus F, Lang B, Pozo-Rosich P, et al. P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer[ J ]. Neurology, 2002,59 (5) :764 - 766.
  • 5Konishi J, Yamazaki K, Chikai K, et al. Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung [J]. Intern Med,2004,43(7) :602 -606.
  • 6Shirai S,Sukoh N,Yamamoto H,et al. A case of small cell lung cancer with paraneoplastic cerebellar degeneration and anti-voltage-gated calcium channel antibody [ J]. Nihon Kokyuki Gakkai Zasshi,2001, 39( 1 ) :41 -44.
  • 7Bruylant K,Crols R,Humbel RL,et al. Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung [ J ]. Clinical Neurology and Neurosurgery,2006,108(4) :415 -417.
  • 8Shams'ili S,Grefkens J,de Leeuw B,et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients [J]. Brain, 2003,126(6) :1409 - 1418.
  • 9Widdess WP ,Tavee JO, Schuele S,et al. Response to intravenous imonunoglobulin in anti-Yo associated paraneoplastie eerebellar degeneration : case report and review of the literature [ J ]. Neumononl, 2003,63(2) :187.
  • 10黄汝成,王华燕.癌性非转移性亚急性小脑变性(附1例报告及文献复习)[J].脑与神经疾病杂志,2001,9(1):49-49. 被引量:1

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