大鼠耐力运动后血浆血管紧张素Ⅱ与尿蛋白组分排泄的相关性研究

THE STUDY OF RELATIONSHIP BETWEEN PLASMA ANGIOTENSIN ⅡAND PROTEIN COMPONENTSIN URINE AFTER ENDURANCE EXERCISE IN RATS

本实验测定了大鼠长时间游泳后即刻及恢复中尿中总蛋白（ＴＰ）、白蛋白（Ａｌｂ）、β微球蛋白（β＿２－ｍＧ）排泄率及血浆血管紧张素Ⅱ（ＡⅡ）活性，分析了ＡⅡ与尿蛋白组分排泄率的相关性。结果表明：ＡⅡ活性与Ａｌｂ排泄率相关性较高（ｒ＝０．６６，Ｐ＜０．０５），ＡⅡ活性与ＴＰ、β＿２－ｍＧ排泄率相关性较低（ｒ＝０．４２，Ｐ＞０．０５；ｒ＝０．３４，Ｐ＞０．０５）。提示ＡⅡ活性在运动后尿蛋白产生机制中与大分子量的Ａｌｂ排泄有较直接关系，而与ＴＰ及小分子量的β＿２－ｍＧ排泄无明显直接关系。

The concentration of plasma angiotensin Ⅱ(AⅡ)and the excretion rates of total protein(TP),albumin(Alb)and β_2-microglobulin(β_2 -mG) in urine were measured at rest,immediatelyafter endurance swimming and 30 minutes after exercise in rat. The results showed that there wassignificant positive correlation between plasma A Ⅱ and urinary Alb excretion(r=0.66, P< 0.05),but no significant correlation between plasma A Ⅱ and urinary TP or β_2-mG excretion after ex-ercise and during recovery period.These findings indicate that the increase in A Ⅱ may affectglomerular permeability after exercise,resulting in increase in Alb,the protein with large molecu-lar weight,excretion in urine,which usually reflects the degree of glomerular permeability.