大鼠胸部照射后支气管肺泡灌洗液成分和肺组织纤溶活力的变化

CHANGES OF THE COMPOSITION OF BRONCHOALVEOLAR LAVAGE FLUID AND FIBRINOLYTIC ACTIVITY OF LUNG TISSUE AFTER THORAX IRRADIATION

大鼠胸部照射γ射线２０Ｇｙ，照射后观察支气管肺泡灌洗液（ＢＡＬＦ）中蛋白质含量、细胞总数和分类及巨噬细胞存活率，肺指数及肺组织纤溶活力，并做了大体解剖和组织学检查。结果为：照射后２周开始ＢＡＬＦ中蛋白质含量、细胞总数和中性粒细胞即明显增多，照射后１——２个月持续处于高水平，高峰在１．５─２个月，照射后３─４个月有所下降，肺指数有相应变化；肺组织纤溶活力则相反，从照射后２周开始持续下降，至照射后２个月已降至最低，接近于零。形态学观察也见到有早期肺水肿和晚期肺萎缩等变化。由上结果可见，大鼠胸部照射后的早期主要为渗出性病变和纤溶活力的降低。文中讨论了照射后血管内皮细胞的损伤在放射性肺损伤发病中的作用。

The protein content,total cell count,differential count and survival rate of macrophages inbronchoalveolar lavage fluid,lung index and fibrinolytic activity of the lung tissue were investi-gated following thorax irradiation in rats.It was found that protein content and cell count beganto increase prominently 2 weeks after irradiation and maintained high level for 2 months.Thelung index changed similarly.However,fibrinolytic activity decreased remarkably after 2 weeksand reached the lowest at the 2nd month after irradiation.The above results suggested that the in-jury of lung vascular endothelial cells after thorax irradiation might be one of the importantpathogenetic factors of radiation-induced lung injury.