摘要
结扎大鼠冠状动脉前降支造成急性心肌梗塞（ＡＭＩ），观察在ＡＭＩ后心室重构早期３、７、１４ｄ心肌线粒体呼吸功能和电子传递组分的改变。结果表明：在心室重构早期，心肌线粒体呼吸Ⅳ态（Ｒ＿４）明显增高（Ｐ＜０．０２）；呼吸Ⅲ态（Ｒ＿３）、呼吸控制率（ＲＣＲ）、磷／氧比（Ｐ／Ｏ）、氧化磷酸化速率（ＯＰＲ）明显下降（Ｐ＜０．００１）；呼吸链电子传递组分显著降低（Ｐ＜０．０５或Ｐ＜０．０１）。提示：ＡＭＩ后心室重构早期心肌线粒体呼吸和氧化磷酸化功能明显受损，是ＡＭＩ后慢性心力衰竭的重要原因。
Acute myocardial infarction(AMI) was produced in rats by ligation of the left anterior des-cending coronary artery. On days 3,7,14 of ventricular remodeling after AMI,myocardialmitochondrial function and electron transport system componts were observed.The resultsshowed that myocardial mitochondrial respiratory state Ⅳ(R_4)increased(P< 0.02), respiratorystate Ⅲ(R_3),respiratory control rate(RCR),Pi /O ratio(P/O)and oxidative phosphorylationrate(OPR)decreased(P<0.001), respiratory chain eletron transport system components obvi-ously decreased P<0.05 or P < 0.01).These results indicate that myocardial mitochondrialrespiratory and oxidative phosphorylation function are damaged in the early phase of ventricularremodeling after AMI and these damages may be an important cause of heart failure followingAMI.
出处
《中国应用生理学杂志》
CSCD
1995年第4期333-336,共4页
Chinese Journal of Applied Physiology
关键词
心肌梗塞
心肌重构
线粒体
呼吸
电子传递组分
acute myocardial infarction
ventricular remodeling
mitochondrial function
electron trans-port system component.Changhai Hospital
The Second Military Medical University
Shanghai 200433
