青中年冠心病患者代谢综合征危险因素的分布与聚集状况分析

Distribution of metabolic syndrome in young and middle age patients with coronary artery disease

目的分析青中年冠心病患者中代谢综合征(MS)危险因素的分布与聚集状况,为早期防治干预提供依据。方法对103例青中年男性[年龄30～50(43.3±5.7)岁]冠心病患者及64例男性[年龄28～50(42.8±6.3)岁]冠状动脉造影正常的对照组的临床特征和生化特点进行比较。按照中华医学会糖尿病学分会标准诊断MS。结果两组在年龄上无差异。冠心病组的吸烟率显著高于对照组,但在冠心病家族史方面两组无差异。冠心病组的总胆固醇(TC)、餐后2h血糖(2hPBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)均显著高于对照组,而HDLC显著低于后者。冠心病组MS的发生率显著高于对照组(P<0.01)。Logistic回归分析显示,吸烟、低HDLC、HOMAIR、MS使青中年人冠心病患病的相对危险度增加。结论青中年冠心病患者多种代谢异常更加严重,对于青中年男性应重视MS的预防,以减少心血管事件的发生。

Objective:To study the distribution of metabolic syndrome in young and middle age patients with coronary artery disease. Method:One hundred and three young and middle age men with coronary artery disease(CAD) and 64 cases age matched men were retrospectively studied. All of them underwent selective coronary angiography.Result:As compared with the group of control, patients with CAD showed higher TC, 2 h PBG,FINS,HOMA-IR,and lower HDL-C values. According to CDS standard, they also had high frequencies of metabolic syndrome(MS), accounting for 48.5%. Multiple logistic regression analysis showed that close relationships exist between CAD and smoking ( OR =2.123), lower HDL-C( OR =1.115), HOMA-IR( OR =1.735), MS( OR =2.542). Conclusion:Metabolic syndrome is common in young and middle age patients with CAD. It is necessary to control multiple risk factors in order to prevent cardiovascular event.