先兆子痫胎盘组织黄嘌呤氧化酶在介导氧化应激反应中的作用

Increasing of xanthine oxidase activity of placenta tissues result in oxidative stress in preeclampsia

目的测定先兆子痫患者胎盘组织匀浆黄嘌呤氧化酶(XOD)、氧自由基的变化,探讨其在妊高征发病机制中的作用。方法选取先兆子痫患者(25例)及正常妊娠妇女(41例)胎盘,测定胎盘组织匀浆液XOD及超氧化物歧化酶(SOD)、丙二醛(MDA)的活性变化。结果先兆子痫患者胎盘XOD、MDA活性与正常足月孕胎盘相比明显升高,而SOD活性却明显降低(P<0.01)。XOD、MDA与SOD活性呈负相关。结论先兆子痫患者胎盘组织黄嘌呤氧化酶活性增加所致的自由基增多,抗氧化能力减弱引起氧化应激导致病情进展。

[Objective] To investigate the role of xanthine oxidase (XOD) and oxygen-derived free radicals in pathogenesis of pregnancy induced hypertension (PIH). [Methods] 25 women with preeclampsia, 41 women with normal pregnancy were closen as study group and control group, respectively. The homogenates of placenta were estracted and the activity of the enzyme and oxygen-derived free radicals was measured. [Results] The activity of xanthine oxidase, malondialdehyde (MDA) of homogenate of placenta in severe PIH were higher than control, while the activity of superoxide dismutase (SOD) was lower than control (P <0.01). Negative correlation between XOD, MDA and SOD were found in study group and control group. [Conclusion] Increase of placenta XOD result in increasing of free radical, decreasing of anti-oxidation ability cause oxidative stress and facilitate state of an illness.