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PPAR-γ受体与急性肺损伤 被引量：2

Peroxisome proliferator-activated receptors gamma and acute lung injury
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摘要 过氧化物酶体增殖物激活受体 γ(PPAR γ)作为一种核转录因子,能与其特异性配体结合,在转录水平上调控多种基因表达。研究证实PPAR γ通过抑制NF κB、AP 1和STATs等炎症信号转导途径,发挥抗炎作用。现就PPAR γ的分子结构、活性调节、抗炎作用机制以及PPAR γ配体对急性肺损伤的保护作用作一综述。
作者 刘东 曾邦雄
机构地区 华中科技大学同济医学院附属协和医院麻醉科
出处 《国外医学（麻醉学与复苏分册）》 CAS 2005年第1期22-25,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
关键词 PPAR-γ 急性肺损伤 过氧化物酶体增殖物激活受体-Γ 信号转导途径 抗炎作用机制 核转录因子 NF-κB STATS 配体结合 基因表达 转录水平 AP-1 分子结构 活性调节 保护作用 特异性 γ配体
分类号 R563 [医药卫生—呼吸系统]
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参考文献22

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同被引文献27

  • 1姜鹏,王建春,钱桂生.过氧化物酶增殖体激活受体与炎症及免疫反应[J].生命的化学,2005,25(3):232-235. 被引量：8
  • 2楼天正,颜碧清,徐俊龙,张宁,刘宏.脓毒症患者血清IL-6、IL-8的动态变化及其意义[J].浙江实用医学,2006,11(1):20-21. 被引量：4
  • 3路一平,邱健.过氧化物酶体增殖物激活受体γ与动脉粥样硬化[J].医学研究生学报,2006,19(6):565-568. 被引量：5
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  • 5Rieote M, Li AC,Willson TM, et al. The peroxisome proliferator -activated receptor-γ is a negative regulator of macrophage activation[J]. Nature, 1998,391 : 79-82.
  • 6Reddy RC, Keshamouni VG, Jaigirdar SH, et a l. Deactivation of murine alveolar maerophages by peroxisome prollferators-activated receptor γ ligands[J]. Am J Physiol Lung Cell Mol Physiol, 2004,286(3) :L613-L619.
  • 7Hammad H, de Heer HJ, Soullie T, et al. Activation of peroxisome proliferation-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma[J]. American J Pathol, 2004,1641:263.
  • 8Blanquart C, et al. Peroxisome proliferatorsactivated receptors: regulation of transcriptional activities and roles in inflammation[J].J Steroid Biochem MoL, 2003,85 (2-5) : 267-273.
  • 9Straus DS, Pascual G, LiM, et al. 152 Deoxy2△12, 142 prostagland in J2 inhibits multiple steps in the NF- κ B signaling pathway[J]. PNAS, 2002, 97 (5) : 4844-4849.
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引证文献2

二级引证文献3

国外医学（麻醉学与复苏分册）
2005年 第1期

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