锂对脑缺血损伤后神经细胞保护的研究进展
被引量：2
Protective effects of Lithium on cerebra after ischemia damage
摘要
锂对脑缺血后神经细胞的保护机制,包括增加营养因子BDNF和抗调亡蛋白BCL 2的表达,激活AKT ,抑制GSK 3β活性,灭活NMDA受体,减少P5 3和Bax等调亡蛋白的表达等。此外,锂还能抑制谷氨酸兴奋性毒性诱导的PKB、CREB的失活及JNK、P38的激活。现就此方面的研究进展作一综述。
出处
《国外医学（麻醉学与复苏分册）》
2005年第1期25-29,共5页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
参考文献29
-
1Nonaka S, Hough CJ, Chuang DM, et al. Chronic lithium treatment robustly pretects neurons in the central nervous system against excitotoxicity by in hibiting N-methyl-D aspartate receptor-mediated calcium influx. Proc Natl Acad Sci USA, 1998,95(5): 2642-2647.
-
2Nonaka S, Chuang DM. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuroreport, 1998,9(9): 2081-2084.
-
3Xu J, Culman J, Blume A, et al. Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death. Stroke, 2003,34(5): 1287-1292.
-
4Saarelainen T, Lukkarinen JA, Koponen S, et al Transgenic mice overexpressing trncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia. MolCellNeurosci,2000,16(2) :87-96.
-
5Hashimoto R, Takei N, Chuang DM, et al. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essen tial step for neuroprotection against glutamate excitotoxicity. Neuropharmacology, 2002,43 (7): 1173-1179.
-
6Neri 1. m, Chuang DM. The nuclear phosphoinositide 3-kinase/Akt pathway:a new second messenger system. Biochim Biophys Acta 2002, 1584 (56) :73-80.
-
7Chalecka-Franaszek E, Chuang DM. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons,Proc Natl Acad Sci U S A1999,96(15):8745-8750.
-
8Einat H. Yuan P, Chen G, et al. The role of the extracellular signal-regu lated kinase signaling pathway in mood modulation. J Neurosci 2003,23(19) :7311-7316.
-
9Segal R A, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci, 1996,19( 1 ) :463-489.
-
10Chen RW, Qin ZH, Ren M, et al. Regulation of c-jun N-terminal ki nase, p38 kinase and AP-1 DNA binding in cultnred brain neurons: roles in glutamate excitotoxicity and lithiun neuroprotection. Journal of Neurochemistry, 2003,84(3): 566-575.
同被引文献38
-
1吴志国,毕方方,黄志凌,李国良,肖波.颞叶癫痫大鼠海马Akt蛋白表达变化的研究[J].中国医学工程,2007,15(4):338-340. 被引量：4
-
2徐淑云 等主编.药理实验方法学(第三版)[M].北京：人民卫生出版社,2002.237.
-
3Datta SR,Brunet A,Greenberg ME,et al.Cellular survival:a play in three Akts.Genes & Development,1999,13(22):2905 -2927.
-
4Chalecka -Franaszek E,and Chuang DM.Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons,Proc Natl Acad Sci U S A1999,96(15):8745 -8750.
-
5Brunet A,Datta SR,and Greenberg ME.Transcription -dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway.Curr Opin Neurobiol 2001,11(3):297 -305.
-
6Xu J,Culman,Blume A,et al.Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death.Stroke,2003,34(5):1287-1292.
-
7Longa EZ,Weinstein PR,Carlson S,et al.Reversible middle cerebral artery occlusion without craniectomy in rat.Stroke,1989,20(1):84 -91.
-
8Huang EJ,Reichardt LF.Trk receptors:roles in neuronal signal transduction.Annu Rev Biochem,2003,72(1):609 -642.
-
9Neri LM,Borgatti P,Capitani S,et al.The nuclear phosphoinositide 3-kinase/AKT pathway:a new second messenger system.Biochim Biophys Acta,2002,1584(2 -3):73 -80.
-
10Nicholson KM,Anderson NG.The protein kinase B/Akt signalling pathway in human malignancy.Cell Signal,2002,14 (5):381 -395.
引证文献2
-
1梅莉,钱燕宁,王斌.氯化锂对大鼠局灶脑缺血再灌后磷酸化蛋白激酶B(P-Akt)表达的影响[J].国际麻醉学与复苏杂志,2006,27(1):19-21.
-
2林慧慧,刘艳青,刘淼,李江丽,宋毅军.Akt1在颞叶癫痫大鼠海马中的表达变化[J].中国现代神经疾病杂志,2012,12(5):581-588. 被引量：4
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-
1黄羚,刘铁钢,马雪颜,白辰,徐竞男,刘邵阳,于河,谷晓红.基于网络药理学的草果知母汤治疗癫痫的机制研究[J].现代中医临床,2020,27(5):31-38. 被引量：5
-
2赵宏,于登君,汤威威,孔令洲,高琪,张宇,王丽红.黄芪-百合-沙棘联用治疗阿尔茨海默病作用机制的网络药理学分析[J].中药新药与临床药理,2021,32(12):1817-1824. 被引量：4
-
3张莞芬,蒋媛静,张永全,羊郑薇.基于网络药理学和分子对接探析二陈汤治疗癫痫的作用机制[J].湖北民族大学学报（医学版）,2024,41(3):12-19.
-
4潘立平,吴秋静,常伟,宋毅军.Toll样受体4在颞叶癫大鼠海马中的表达研究[J].中国现代神经疾病杂志,2013,13(12):1021-1026.
-
1贺双腾.缺血性脑损伤时神经生长因子的表达[J].国外医学（脑血管疾病分册）,1998,6(1):13-17. 被引量：21
-
2范开明,黄燕虹,叶志刚,万震威,胡峥嵘.异丙嗪对大鼠局灶性脑缺血损伤的保护作用[J].汕头大学医学院学报,2007,20(1):40-41. 被引量：3
-
3摄入微量锂元素能延年益寿[J].家庭医药（快乐养生）,2011(4):72-72.
-
4英研究出治疗躁郁症新方法[J].江苏卫生保健（今日保健）,2010(1):55-55.
-
5杨卓欣,张家维.缺血性脑损伤神经干细胞与突触可塑性研究进展[J].安徽中医学院学报,2004,23(4):55-57.
-
6唐洲平,郭守刚,彭岚,朱遂强,方思羽,张苏明.脑出血灶周缺氧诱导因子-1α、热休克蛋白70的表达[J].华中科技大学学报（医学版）,2004,33(1):49-51. 被引量：4
-
7高芳.依达拉奉联合丹参多酚酸盐治疗急性脑梗死的疗效[J].中国老年学杂志,2013,33(23):5991-5992. 被引量：43
-
8微量锂元素有延寿作用[J].大众健康,2011(3):13-13.
-
9胡跃强,唐农,董少龙,刘尊敬,祝美珍,胡玉英,王棕可.缺血预处理对大鼠脑缺血再灌注损伤神经细胞的保护作用[J].中国老年学杂志,2012,32(8):1630-1631. 被引量：3
-
10张拥波,余刚,董为伟.缺血性脑卒中病人的临床用药[J].中国医院药学杂志,2002,22(7):423-425. 被引量：1
