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NMDA受体与吸入麻醉药的镇痛作用的关系 被引量：4

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摘要 N-甲基-D-天门冬氨酸(N-methyl-D-aspartate ,NMDA)受体是中枢神经系统中主要的兴奋性氨基酸受体,近年来的研究表明吸入麻醉药镇痛作用与NMDA受体有密切的关系。
作者 杭黎华 戴体俊 曾因明
机构地区 徐州医学院江苏省麻醉学重点实验室
出处 《国外医学（麻醉学与复苏分册）》 2005年第2期108-111,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
关键词 NMDA受体 镇痛作用 吸人麻醉药 N-甲基-D-天门冬氨酸 兴奋性氨基酸受体 吸入麻醉药 中枢神经系统
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献24

  • 1Berrino L, Oliva P, Massimo F, et al. Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.Eur J Pain,2003,7(2): 131-137.
  • 2Hama A, Woon Lee J, Sagen J. Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats. Eur J Pharmacol,2003,459(1) :49-58.
  • 3Tao YX, Johns RA. Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate or nitric oxide-produced spinal thermal hyperalgesia. Eur J Pharmacol,2000,392(3): 141-145.
  • 4Nishikawa K, MacIver MB. Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses. Anesthesiology,2000,92(1) :228-236.
  • 5Cheng G, Kendig JJ. Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology,2000,93(4): 1075-1084.
  • 6Ishizaki K, Yoshida N, Yoon DM, et al. Intrathecally administered NMDA receptor antagonists reduce the MAC of isoflurane in rats. Can J Anaesth,1996,43(7) :724-730.
  • 7Docquier MA, Lavand' homme P, Ledermann C, et al. Can determining the minimum alveolar anesthetic concentration of volatile anesthetic be used as an objective tool to assess antinociception in animals? Anesth Analg,2003,97(4): 1033-1039.
  • 8Sumikura H, Arendt-Nielsen L. MAC reduction after intrathecal coadministration of GABA(A) agonist and glutamate antagonist in rats. J Anesth,2003,17(2) :92-97.
  • 9McFarlane C, Warner DS, Dexter F. Interactions between NMDA and AMPA glutamate receptor antagonists during halothane anesthesia in the rat.Neuropharmacology, 1995,34 (6): 659-663.
  • 10Stabernack C, Sonner JM, Laster M, et al. Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane. Anesth Analg, 2003,96( 1 ): 102-107.

二级参考文献6

  • 1李锋,笪翠娣,周敬修.大鼠尾部痛刺激后脊髓骶尾段一氧化氮合酶的变化[J].中国组织化学与细胞化学杂志,1998,7(3):43-46. 被引量：3
  • 2Malmberg AB, Yaksh TL. Spinal nitric oxide synthase inhibition block NAMD-induced thermal hyperalgesia and antinocicption the formalin test in rats. Pain. 1993, 54:291-300.
  • 3Meller ST, Dykstra D. Production of endogenous nitric oxide and cyclase are required for N-methyl D-aspartate-produced facilitation of the nociceptive tailflick reflex. Eur J Pharrnocol, 1992, 214: 93-96.
  • 4Lam HH, Hanley DF, Trapp BD, et al. Induction of spinal cord neuronal nitric oxide synthase after formalin injection in the rat hindpaw. Neurosci Lett, 1996, 210: 201-204.
  • 5Wang JI, Rousseau DL, Abesound HM, et al. Heme coordination of NO in NO synthase. Proc Natl Acad Sci USA, 1994, 91:10512-10516.
  • 6靳艳卿,段世明,王钧,曾因明.侧脑室注射蝇蕈醇和荷包牡丹碱对大鼠异氟烷最低麻醉浓度的影响[J].中国药理学与毒理学杂志,2000,14(4):287-290. 被引量：8

共引文献5

同被引文献43

引证文献4

二级引证文献8

国外医学（麻醉学与复苏分册）
2005年 第2期

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