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中性粒细胞蛋白酶与心肺转流肺损伤 被引量：1

Current concepts of neutrophil proteinases in acute lung injury caused by cardiopulmonary bypass.
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摘要 心肺转流肺损伤一直是临床关注的重点。心肺转流过程中,中性粒细胞在肺部积聚、激活并释放出中性粒细胞蛋白酶,参与肺损伤的发生、发展过程中的关键性环节。采用非特异性或特异性的措施抑制中性粒细胞蛋白酶活性,以期预防或减轻心肺转流肺损伤。
作者 王寿勇 张诗海 姚尚龙
机构地区 华中科技大学同济医学院附属协和医院麻醉科
出处 《国外医学（麻醉学与复苏分册）》 2005年第2期111-114,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
基金 国家自然科学基金资助项目 (3 0 2 712 5 5 )
关键词 中性粒细胞 心肺转流 肺损伤 蛋白酶活性 转流过程 非特异性 关键性 时间值
分类号 R563.8 [医药卫生—呼吸系统]
  • 相关文献

参考文献24

  • 1Asimakopoulos G, Smith PL, Ratnatunga CP, et al. Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass. Ann Thorac Surg, 1999,68 (3):1107-1115.
  • 2Picone AL, Lutz CJ, Finck C, et al. Multiple sequential insults cause post-pump syndrome. Ann Thorac Surg, 1999, 67(4):978-985.
  • 3Carney DE, Lutz CJ, Picone AL, et al. Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass. Circulation,1999, 100(4) :400-406.
  • 4Moraes TJ, Chow CW, Downey GP. Proteases and lung injury. Crit Care Med, 2003,31(4 Suppl) :S189-194.
  • 5Messent M, Sinclair DG, Quinlan GJ, et al. Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress.Crit Care Med, 1997,25(3) :425-429.
  • 6Kim WG, Lee BH, Seo JW. Light and electron microscopic analyses for ischaemia-reperfusion lung injury in an ovine cardiopulmonary bypass model. Perfusion,2001,16(3) :207-214.
  • 7Fujishima S, Aikawa N. Neutrophil-mediated tissue injury and its modulation. Intensive Care Med, 1995,21 (3): 277-285.
  • 8Vu TH, Werb Z. Matrix metalloproteinases: Effectors of development and normal physiology. Genes Dev,2000,14(17) :2123-2133.
  • 9Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem, 1999,274(31 ): 21491-21494.
  • 10Ariel A, Yavin EJ, Hershkoviz R, et al. IL-2 induces T cell adherence to extracellular matrix: Inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase. J Immunol, 1998, 161 ( 5 ): 2465-2472.

二级参考文献30

  • 1王寿勇,张诗海,姚尚龙.中性粒细胞蛋白酶与心肺转流肺损伤[J].国外医学（麻醉学与复苏分册）,2005,26(2):111-114. 被引量：1
  • 2江宏磊,张慧,郑卫,程元荣.弹性蛋白酶抑制剂Fw 99468抑制动力学的研究[J].海峡药学,2005,17(6):168-170. 被引量：3
  • 3马国尔,郑金旭.中性粒细胞弹性蛋白酶抑制剂研究现状[J].国际呼吸杂志,2006,26(4):257-259. 被引量：7
  • 4张爱军,郭继芬,赵玲,赵毅民,王亚芹.LC-MS/MS法检测西维来司他原料药中的降解产物[J].中国新药杂志,2006,15(9):712-715. 被引量：3
  • 5陆志华.高岩.SARS药物治疗和最新研究进展[J]药物与临床,2003(5).
  • 6Yamamoto H;Koizumi T;Kaneki T.Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat[J],2000(02).
  • 7Ishikawa N;Oda M;Kawaguchi M.The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury[J],2003(05).
  • 8Yamaguchi K;Aze Y;Shimizu K.Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (4). 6-month repeated dose intravenous toxicity study in rats with 1-month recovery test,1998(z3).
  • 9Okamoto M;Ide M;Suzuki H.Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (5). 6-month repeated dose intravenous toxicity study in dogs with 1-month recovery test,1998(z3).
  • 10Nishimura T;Chihara N;Sugai S.Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy)phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na)(2).Study for effects on pre- and postnatal development in rats, including maternal function,1998(z3).

共引文献7

同被引文献29

  • 1江宏磊,张慧,郑卫,程元荣.弹性蛋白酶抑制剂Fw 99468抑制动力学的研究[J].海峡药学,2005,17(6):168-170. 被引量：3
  • 2马国尔,郑金旭.中性粒细胞弹性蛋白酶抑制剂研究现状[J].国际呼吸杂志,2006,26(4):257-259. 被引量：7
  • 3张爱军,郭继芬,赵玲,赵毅民,王亚芹.LC-MS/MS法检测西维来司他原料药中的降解产物[J].中国新药杂志,2006,15(9):712-715. 被引量：3
  • 4陆志华.高岩.SARS药物治疗和最新研究进展[J]药物与临床,2003(5).
  • 5Yamamoto H;Koizumi T;Kaneki T.Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat[J],2000(02).
  • 6Ishikawa N;Oda M;Kawaguchi M.The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury[J],2003(05).
  • 7Yamaguchi K;Aze Y;Shimizu K.Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (4). 6-month repeated dose intravenous toxicity study in rats with 1-month recovery test,1998(z3).
  • 8Okamoto M;Ide M;Suzuki H.Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (5). 6-month repeated dose intravenous toxicity study in dogs with 1-month recovery test,1998(z3).
  • 9Nishimura T;Chihara N;Sugai S.Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy)phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na)(2).Study for effects on pre- and postnatal development in rats, including maternal function,1998(z3).
  • 10Wang HG;Shibamoto T;Miyahara T.Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung[J],1999(01).

引证文献1

二级引证文献8

国外医学（麻醉学与复苏分册）
2005年 第2期

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