IL-6和IL-8在乙型肝炎后肝硬化患者中的临床意义探讨

To investingate Clinical Significance of Interleukin-6 and Interleukin-8 in Patients with Type B Posthepatitic Cirrhosis

目的探讨乙型肝炎后肝硬化患者血清IL-6和IL-8的临床意义。方法67例乙型肝炎后肝硬化患者采用酶联免疫吸附试验(ELISA)双抗体夹心法检测血清IL-6和IL-8,根据Child-pugh分级分为A组(22例)、B组(25例)、C组(20例),并与正常对照组65例作比较。结果乙型肝炎后肝硬化患者血清IL-6和IL-8明显高于对照组(P<0.01),且A、B、C三组各项指标比较差异非常显著(P<0.01)。结论血清IL-6和IL-8水平是反映乙型肝炎后肝硬化肝功能损害程度及判断病情预后的重要指标。

Objective To investigate clinical significance of Interlukin-6(IL-6)and Interleukin-8(IL-8)in patients with type B posthepatitc dirrhosis.Methods IL-6and IL-8 were detected in 67 patients with type B postheatitic cirrhosis by ELISA method,67 patients were divided into A、B、C groups according to the Child-pugh grade and matched with normal control group. Results IL-6and IL-8 in patients with type B posthepatitic cirrhosis were higher than those in normal control group(P<0.01).There were significant difference among A、B、C group(P<0.01).Conclusion IL-6 and IL-8 were important target to reflect hepatic function damage of type B posthepatitic cirrhosis and to judge prognosis of posthepatic cirrhosis.