慢性活动性肝炎患者生化指标组间典则相关分析

The canonical correlation analysis of biochemical marker in chronic active hepatitis patients

目的分析慢性乙型肝炎患者多个血清生化指标间相关关系,探讨多因素间的联系。方法将生化指标分成肝功能和纤维化与凝血两大类指标,采用典则相关分析法研究两因素集团间联系。结果第一典则相关系数反映胆碱脂酶、白蛋白、低密度脂蛋白胆固醇(LDL C)和透明质酸(HA)、Ⅳ型胶原(PCⅣ)存在依存关系,在典则变量上呈现负相关,相关系数(r1)为-0.87824,第二典则相关系数(r2)决定总胆红素和凝血酶原时间(PT)、国际标准化比值(INR)、活化部分凝血激酶时间(APTT)的正相关关系,其r2=0.75059,而第三典则相关系数(r3)决定高密度脂蛋白胆固醇(HDL C)和Ⅲ型胶原(PCⅢ)的正相关关系,其r3=0.73733。结论集团因素的检验指标可采用多元典则相关分析法有效地得出其组间相互联系的指标。

Objective To find the correlation of different serum biochemical markers in chronic active hepatitis patients. Methods Biochemical markers were divided into hepatic function group and fibrosis group. The canonical correlation analysis was employed to analysis the relations between this two groups. Results The first canonical correction variables is -0.878 24, and the cholinesterase, albumin and lower density cholesterol showed negative correlation with HA and PCⅣ, and the total bilirubin showed positive correlation with PT, INR and APTT for second canonical correlation variables 0.750 59. The third canonical correction variables reflected the positive correlation between high density cholesterol and the PCⅢ and the value was 0.737 33. Conclusions The canonical correlation analysis can effectively find the correlation among the different groups of biochemical markers.