高灵敏度C反应蛋白对急性冠状动脉综合征近期预后的判断价值

The value of high-sensitivity C-reactive protein for predicting the short-term prognosis in patients with acute coronary syndrome

目的:评估血清高灵敏度C反应蛋白(hs-CRP)对急性冠状动脉综合征(ACS)近期预后的判断价值。方法:测定血清hs-CRP、纤维蛋白原(Fg)、肌酸磷酸激酶(CPK)和其同工酶(CK-MB)及心肌肌钙蛋白I(cTnI),并观察住院期间的不良心血管事件发生率,对ACS病人近期预后进行分析。结果:发生不良心血管事件组hs-CRP水平高于未发生组,且hs-CRP水平与住院期间不良心血管事件存在正相关(rs=0.37,P=0.008),血清hs-CRP升高组住院期间不良心血管事件发生率明显高于血清hs-CRP正常组。结论:hs-CRP可以较灵敏地预测ACS患者不良心血管事件的发生,其预测的敏感性比Fg及cTnI等血清标志物好。

Objective To evaluate the value of high-sensitivity C-reactive protein hs-CRP  for predicting the short-term prognosis in patients with acute coronary syndrome ACS. Methods Serum level of hs-CRP fibrinogenFg cardiac troponin I cTnIcreatine kinase(CPK)and isoenzyme MB (CK-MB)were measured. The incidence of major cardiac events within hospitalization was assessed. Results The serum level of hs-CRP in the group of cardiac events were significantly higher than that in the group of non- cardiac events Serum hs-CRP was in direct proportion to the occurrence of major cardiac events(rs=0.37 P=0.008)the incidence of major cardiac events within hospitalization was higher in patients with an abnormal hs-CRP than in patients with a normal CRP. Conclusion The present study indicates that serum hs-CRP can sensitively predict the occurrence of major cardiac events in ACS the predict sensitivity may be higher with hs-CRP than that with Fg or cTnI.