应用HBIG阻断乙肝病毒母婴传播的研究

Study on interruption of the vertical transmission of HBV by HBIG

目的:观察孕妇注射乙型肝炎免疫球蛋白(HBIG),新生儿生后接种乙型肝炎疫苗联合注射HBIG的干预方法,对乙型肝炎病毒(HBV)母婴垂直传播的阻断作用。方法:185例HBsAg(+)和/或HBeAg(+),无乙型肝炎症状的孕妇分为干预组(108例孕妇,109例新生儿)和对照组(77例孕妇,77例新生儿)。干预组自怀孕28周起每月肌注HBIG200IU,两组新生儿出生时、1月和6月接种乙型肝炎疫苗和多次注射HBIG。所有婴儿取血检测HBsAg和HBeAg等乙型肝炎血清标记物,并随访至生后1年。结果:在出生时、6月和12月,干预组婴儿HBsAg(+)和/或HBeAg(+)例数皆低于对照组。结论:应用该方法对阻断HBV母婴垂直传播有效。

Objective To investigate the interruptive effect of intervention therapy on mother-infant vertical transmission of hepatitis B virus (HBV) of injectting hepatitis B immunoglobulin(HBIG) in pregnancy and inoculated hepatitis B vaccine plus HBIG on neonates. Methods 185 cases of pregnant women (186 cases neonates) who were asymptomatic carrier of HBsAg and/or HBeAg were divided into two groups. The intervention group (77cases pregnant women 78 cases neonates) received 200 IU of HBIG intramuscularly (IM) once a month since the 28th week of gestation. All neonates of two groups were inoculated with HBV vaccine IM at 0 1 and 6 months of age and received HBIG IM once a ten-days from birth to 3 months of age. HBV seromarkes of HBsAg and HBeAg were tested. All infants were followed-up for 1 year. Results The cases of positive HBsAg and/or HBeAg of the intervention group were less than those of the control group at 0 6 and 12 months of age. Conclusion The intervention therapy is effective to interruptting mother-infant vertical transmission of HBV.