改良法无肝素透析的临床应用体会

Clinical application of modified method in non-heparin dialysis

目的探索一种无肝素透析的新方法,以改善无肝素透析的效果和降低透析器凝血发生率。方法62例有出血倾向的尿毒症患者随机交替采取传统法和改良法进行无肝素透析,构成2组。监测透析前后血尿素氮和肌酐的浓度变化,及观测透析器凝血的发生率。结果2种方法透析前血尿素氮、肌酐浓度相比较差异无显著性(P>0.05);透析后改良法血尿素氮、肌肝浓度显著低于传统法(P<0.01),透析器凝血发生率改良法较传统法显著降低(P<0.01)。结论改良法无肝素透析能改善透析效果和降低透析器凝血发生率,较传统法有显著的优点。

[Objective] To study a new method in non-heparin dialysis, which could improve the dialysis effect and reduce the incidence of coagulation in dialyser. [Methods] Sixty-two uremia patients with hemorrhagic tendency were processed non-heparin dialysis by traditional method and modified method alternatively. The concentrations of BUN and creatine (Cr) before and after dialysis were monitored in two groups and incidence of coagulation′s of dialysers were observed. [Result] The concentration of BUN and Cr before dialysis had no signification in two groups (P >0.05), but differed significantly after dialysis (P <0.01). The incidence of coagulation in dialyser in modified method was less than that in traditional method. [Conclusion] The modified method is better than traditional method in reducing the incidence of coagulation in dialyser and modifying effect of Hemodialysis.