成人中胚叶肾瘤

Adult mesoblastic nephroma

目的 探讨成人中胚叶肾瘤的组织发生、临床病理学特点及其鉴别诊断要点。方法 通过形态学和免疫组化对 1例成人中胚叶肾瘤进行分析并复习相关文献。结果 肿瘤组织由上皮和间叶细胞组成 ,间叶细胞呈梭形 ,核椭圆形 ,染色深 ,可见小核仁 ,呈不同程度的平滑肌或肌纤维母细胞分化。肿瘤的外周和中央散在一些小管和囊腔。梭形细胞vimentin、SMA(+) ,而CKpan和EMA(- )。结论 成人中胚叶肾瘤是一种少见的肾混合性良性肿瘤 ,需结合免疫组化与肾恶性肿瘤鉴别。

Objective To investigate the histogenesis, clinicopathological features of adult mesoblastic nephroma (MN) and its differential diagnosis. Methods A case of adult MN was studied by light microscopy and immunohistochemistry. The morphological features and the relevant literatures were reviewed. Results The tumor was composed of epithelial and mesenchymal cells. The mesenchymal cells were spindle fibroblasts which displayed smooth muscle cell or myofibroblastic differentiation, and oval nuclei and small nucleoli were observed. The isolated tubules or cysts were seen at the periphery and center of the tumor. Immunohistochemically, the stromal cells were positive for Vim and SMA, but negative for CK and EMA. Conclusion The adult MN is a rare benign composite renal tumor that can be differentiated from other malignant renal tumor by immunohistochemistry and treated successfully by complete excision.