核转录因子-κB在子宫内膜异位症中的表达及其意义

Expression of nuclear factor-Kappa B and its significance in endometriosis

目的 检测核转录因子 κB(NF-κB)在子宫内膜异位症 (EM)中的表达 ,探讨其与EM发病机制的关系。方法 采用免疫组化SP法检测NF-κB在内膜组织中的表达情况 ,并用组织学评分对其进行半定量统计 ,比较其表达强度。结果 NF-κB主要定位于腺上皮细胞的胞质中 ,在异位内膜的基质细胞、螺旋小动脉的血管内皮细胞也有少量表达。子宫内膜异位症患者中异位内膜组表达强度显著高于在位组及对照组 (P <0.0 1) ,各组中分泌期与增生期表达强度比较前者高于后者 (P <0.0 5 )。结论 NF-κB在EM患者中的异常表达 。

Objective To determine the nuclear factor-Kappa B (NF-κB) expression in endometriosis and to explore the possible role of NF-κB in the pathogenesis of endometriosis. Methods Expression of NF-κB in normal endometrium、 ectopic endometrium and eutopic endometrium in endometriosis were detected by immunohistochemistry. The results were analyzed by SPSS11.0 statistical software. Results Expression levels of NF-κB in ectopic and eutopic endometriotic tissues were significantly higher than that in the normal endometrium (P<0.01), and the expression changed with the normal menstrual cycle in the three kinds of endometrium. Conclusion The expression of NF-κB in normal endometrium plays a very important role in circle changes of endometrium. It is suggested that stronger expression in patients of endometriosis may relate to the pathogenesis of endometriosis.