高乌甲素的临床应用

Clinical application of Lappaconitine hydrobromide

高乌甲素具有抗炎消肿、降温解热与局部麻醉作用。高乌甲素在临床中使用可采取静脉滴注、肌肉注射和口服等多途径作镇痛治疗。高乌甲素对亚重度疼痛镇痛较好,但对重度疼痛镇痛效果不佳,与使用剂量低有关。今后可从增加剂量、复合其他中西药及改进用药技术等方面继续深入探索,以进一步提高其镇痛效果。

Lappaconitine hydrobromide can remove inflammation and swelling, lower temperature and relieve heat. It also can be used for local anesthesia. Clinically lappaconitine hydrobromide can be applied via i.v., i.m. or p.o. for analgesic treatment. Lappaconitine has better effect for moderate pain than for severe pain, which may be associated with the low dose. Future efforts should be made in increasing dosage, combining lappaconitine hydrobromide with other drugs and improving drug delivery technique.