O型孕妇血清抗体效价与新生儿ABO溶血病发生的关系

The relationship between the titer of serum antibody of blood-type O gravidas and the occurrences of ABO hemolytic disease among newborn infants

目的:探讨232例O型血孕妇血型抗体效价与新生儿溶血病及高胆红素血症发生的关系。方法:根据O型孕妇妊娠20～32周测定的IgG抗A(B)效价,把新生儿分成4组(≤1∶32,1∶64,1∶128,≥1∶256),取新生儿的静脉血进行改良直接法抗人球蛋白试验抗体释放试验和游离抗体3项试验以证实ABO溶血病,监测新生儿黄疸的发展,对新生儿进行早期治疗。结果:新生儿ABO溶血的发生率与母亲抗体效价相关,效价越高,新生儿溶血病发生率越高,差异有显著性(P<0.05),高胆红素血症的发生率为也呈上升的趋势,差异有显著性(P<0.05)。结论:随着孕妇IgG血型抗体效价的升高,新生儿ABO溶血病和高胆红素血症的发生率升高,应对新生儿黄疸进行早期的监测及治疗。

Objective:To study the relations between the blood type antibody titer of 232 blood-type-O gravidas and the occurrences of hemolytic disease and jaundice among newborn infants.Methods:According to the titer of serum IgG antibody A(B) of blood-type O gravidas taken during their 20 to 32 week gravidity, divide the newborn infants into four groups (≤1∶32,1∶64,1∶128,≥1∶256),carry out three kinds of tests with the infants' blood of vein including the serum coombs test, antibody release test and free antibody test so as to verify ABO hemolytic disease, to monitor the development of icterus and carry out early treatment.Results:The occurrence of newborn infant's ABO hemolytic disease is in connection with its mother's antibody titer.The higher the titeris,the higher the occurrence rate of hemolytic diseaseis. The difference is remarkable (P<0.05). At the same time the frequency of jaundice is also higher with a remarkable difference(P<0.5).Conclusion:With gravida's rise of the titer of serum IgG antibody, newborn infant tends to have a frequent occurrence of ABO hemolytic disease and jaundice. It is necessary to undertake supervision and treatment of infants' jaundice in an early stage