益肾健脾方对老年虚证T细胞亚群、可溶性白细胞介素－2受体及红细胞免疫的影响

Effect of Yishen Jianpi Drugs on T Lymphocyte Subsets,Soluble Interleukin-2 Receptor and Red Blood Cell Immunity of Senile Deficiency Syndrome Patients

本研究动态检测了益肾健脾中药对老年虚证的Ｔ细胞亚群、可溶性白细胞介素－２受体（ＳＩＬ－２）及红细胞免疫等指标的影响，并以健康献血员为对照。结果：老年虚证组Ｔ淋巴细胞亚群ＣＤ_３、ＣＤ_４显著降低，ＣＤ_８显著增加，故ＣＤ_４／ＣＤ_８显著下降（Ｐ＜０．０１）；ＳＩＬ－２Ｒ显著增高（Ｐ＜０．０１）；红细胞免疫指标红细胞Ｃ_３ｂ受体花环率（ＲＢＣ－Ｃ_３ｂＲＲ）显著降低，红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）增高（Ｐ＜０．０１）。进而分析发现老年虚证组ＣＤ_４／ＣＤ_８与ＳＩＬ－２Ｒ呈负相关（ｒ＝－０．５７２，Ｐ＜０．０１），而与ＲＢＣ－Ｃ_３ｂＲＲ呈正相关（ｒ＝０．４３５，Ｐ＜０．０２）。经益肾健脾治疗后，虚象减轻，免疫指标改善，呈相对应负性改变（Ｐ＜０．０１与Ｐ＜０．０５），但与正常对照比较，除红细胞免疫指标接近正常外，其余仍低于正常（Ｐ＜０．０１），且上述相关性消失。提示益肾健脾对免疫功能有显著改善作用，但仍低于正常。

To evaluate the effect of Yishen Jianpi drugs(YJD) on immunological function of the Senile Deficiency Syndrome(SDS) patients,T lymphocyte subsets,soluble interleukin-2 receptor(SIL-2 R),the red blood cell immunity,the rate of red blood cell C 3 b receptor rosette(RBC-C 3 bRR) and red blood cell immune complex rosette(RBC-ICR)were dynamically investigated in 31 SDS patients as well as in normal controls.Results:the percentage of CD3,CD4 and CD4/CD8 ratio and the rate of RBC-C 3 bRR in SDS were all significantly lower than that of control(P<0.01).The further analysis also revealed that between the immunological indices of CD4/CD8 ratio and SIL-2 R in SDS patients were markedly negative correlated(r=0.572,P<0.01) while positive correlated(r=0.435,P<0.02) markedly between CD4/CD8 and RBC-C 3 bRR.After treatment with YJD,in comparing pretreatmentally,all the above-mentioned immunological indices,following the relief of clinical manifestation of SDS,they were corresponding negatively changed,and there were marked significance(P<0.01) except red blood cell immunity.It suggested that YJD would markedly improve and/or regulate immunological function in SDS.