镉对大鼠胰岛素水平的影响

Effects of cadmium on levels of insulin in rats

目的研究镉对机体胰岛素水平的影响。方法采用随机区组方法,96只SD大鼠给予不同剂量的镉(CdCl20、50、100和200mgL),饮水染毒30天、60天、90天。测定不同染毒时间大鼠血胰岛素、血液、尿液中镉含量的改变以及肝、肾和胰脏中镉含量的改变。结果染毒组大鼠在染毒30天中、高剂量组和染毒60天的中剂量组血清胰岛素水平显著降低。各剂量组大鼠血、尿和胰脏中镉含量有显著增加。但胰脏中镉含量低于肾脏和肝脏。结论镉可以在胰脏组织蓄积,引起胰岛素水平降低。

Objective\ To explore the effect of cadmium on insulin in rats. Methods 96 of SD rats were administered with cadmium at different doses ~0, 50, 100, 200 mg/L) by drinking water for 30 days, 60 days, and 90 days. The levels of insulin,the contents of cadmium in the blood,urine, and tissues ~liver,kidney, and pancreas) were determined. Results The level of insulin were decreased in the groups of 100 and 200 mg/L at the 30-day and in the group of 100mg/L at the 60-day. Cadmium in blood and tissues ~liver, kidney, and pancreas) were higher in exposed groups than those in control group. But the contents of cadmium in pancreas are lower than that in kidney and liver. Conclusion It is suggested that cadmium could be accumulated in pancreas. Then it maybe related to the change of the levels of insulin in serum.