邻苯二甲酸酯雌性生殖毒性研究进展

Progress in phthalate ester toxicity in the female reproductive system

邻苯二甲酸酯是一类产量大、用途广而且严重污染环境的化合物,流行病学调查证实了邻苯二甲酸酯的暴露与女性生殖功能损害的关系。本文就邻苯二甲酸酯对雌性生殖功能损害的体内、体外实验及毒性的机制进行了回顾。

Phthalates are high-production-volume synthetic chemicals with ubiquitous environmental pollution because of their use in plastics and other common consumer products. Epidemiological evidence suggests the relation between women-exposure and the potential health hazards of Phthalates. Here we review research about how phthalates interact with the female reproductive system in vivo, in vitro models, embryo development toxicity and the mechanisms of female toxicity.