肝气虚证临床证型的病理生理学初步研究

Preliminary Study on Pathophysiology of Liver-Qi Deficiency Syndrome

本研究从理论与临床角度探讨了肝气虚证患者病理生理学的改变。临床病例调查表明，本证作为疾病的隐性阶段或外在表现，在临床上广泛存在，占气虚证的１８．８５％。对肝气虚证患者进行了血清乳酸脱氢酶及其同工酶、ＧＰＴ、，总蛋白、白蛋白及Ａ／Ｇ比值、多巴胺β羟化酶、微量元素锌及铜等指标的观察，初步揭示其实质。为了排除混杂与干扰，对肝气虚证应区分肝病与非肝病。

The authors advocate a program for diagnosing Liver-Qi Deficiency Syndrome(LQDS) based on the TCM theory and clinical practice.Through investigation, LQDS was found to be widely existed as latent period or as external manifestation, which occupied 18.85% in Qi Deficiency Syndrome.The subjects were divided into four groups including normal group, Spleen-Qi Deficiency Syndrome(SQDS) group, LQDS with Liver diseases(LD) and LQDS with non-Liver diseases(NLD) group.In order to explore the essence,the simultaneous determinations were done on lactate dehydrogenase (LDH) and its isoenzyme,dopamineβ-hydroxylase(DβH),trace element Zn and Cu, and other serological indexes such as GPT, TP, Alb,A/G, etc.The results were, the content of LDH and trace element Zn in both LQDS-NLD and SQDS were significantly lower than that of normal group.DβH reflecting sympathetic nerve function in LQDS-NLD was significantly higher than that of both normal and SQDS group, comparing LQDS-LD and LQDS-NLD group, the content of GPT, LDH,LDHS and trace element Cu in former was significantly higher than that of the latter, but the content of TP,Alb,A/G, DβH and Zn in former was remarkably lower than that of the latter.In order to avoid confusion, in studying this syndrome,one should distinguish LD and NLD.