锡类散治疗消化性溃疡作用机制的研究

Study on Therapeutic Mechanism of Xi Lei Powder for Peptic Ulcer

选择经胃镜诊断为消化性溃疡活动期患者１２８例，经锡类散治疗４周后，血浆与胃、十二指肠粘膜组织前列腺素Ｅ２（ＰＧＥ２）含量明显高于治疗前，有显著性差异（Ｐ＜０．０１）。治疗后幽门螺旋杆菌（ＨＰ）转阴率为６３．３％，且分布密度减低，与治疗前比较有显著性差异（Ｐ＜０．０１）。本研究结果表明，锡类散使溃疡愈合可能与该药促进胄肠粘膜组织合成ＰＧＥ２增多和抑制ＨＰ的生长、繁殖以及清除有关，而不是由于抑制胃酸分泌和胃泌素释放所致。

We studied 128 patients with active peptic ulcer diagnosed by gastro-endoscopy four weeks after treatment with Xi Lei powder,PGE_2 levels in both serum and gastro-duodenal mucosa were significantly higher than that before the treatment,the difference was significant(P<0.01).The rate of negative conversion of Helicobacter pylori(HP) showed in 63.3% of cases.The distributed density of HP significantly reduced,the difference was significant(P<0.01).These results indicated that Xi Lei powder could heal ulcer probably owing to the increasing of the PGE2 level in gastroduodenal mucosa,it inhibited the growth and reproduction of HP,and eliminated the HP,but did not inhibit the secretion of gastric acid and release the gastrin.