补阳还五汤治疗冠心病的临床研究及其作用机制探讨

Clinical Study on Effects of Buyang Huanwu Decoction on Coronary Heart Disease

１０２例冠心病（ＣＨＤ）患者随机分为中药补阳还五汤治疗组和西药对照组进行临床研究。结果：（１）补阳还五汤组患者血清脂质过氧化物（ＬＰＯ）、载脂蛋白Ｂ１００（ａｐｏＢ１００）水平及ＬＰ０／超氧化物歧化酶（ＳＯＤ）、ａｐｏＢ１００／ａｐｏＡ１比值明显降低，而血清ＳＯＤ、ａｐｏＡ１水平明显升高；（２）补阳还五汤缓解心绞痛的效果与对照组相似，但心电图改善优于对照组。提示补阳还五汤具有治疗ＣＨＤ的作用，抗脂质过氮化和调节载脂蛋白代谢可能是其重要的作用机制。

cases of coronary heart disease(CHD) were divided randomly into two groups,70 cases were given orally the Buyang Huanwu Decoction(BYHWD) for 15 days and were compared with 32 control patients.The effect of BYHWD in treating angina pectoris and the change of EKG before and after the treatment were observed.The results were as follows:in BYHWD group the serum level of lipoperoxide(LPO),apolipoprotein(apo) B100,LPO/SOD(superoxide dismutase) and apo B100/apo A1 were lowered remarkably,the serum of SOD and apo A1 were elevated significantly(P<0.01) comparing with the control group.The total effective rate of treating angina pectoris was 91.4%.But the difference was insignificant compared with the control group (P <0.05).The EKG improvement rate was 85.7% in BYHWD group,the difference was very significant comparing with control group(P<0.05).The results indicated that BYHWD had a good effect on removing the oxygen free radicals,reducing the injury of LPO and regulating the apolipoprotein metabolism in the patients with CHD.Therefore BYHWD is an effective TCM remedy for CHD.