血管通抗实验性家兔动脉粥样硬化的作用

Effect of Xueguantong on Inhibiting Experimental Atherosclerosis in Rabbits

血管通是血府逐瘀汤的颗粒剂。本实验用喂饲胆固醇饲料形成的实验性家兔动脉粥样硬化（ＡＳ）模型，观察血管通对ＡＳ家兔主动脉内膜斑块形成的影响，以及对血脂、血小板聚集及粘附功能的影响。结果表明：血管通能明显降低血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）含量的水平，抑制血小板粘附、聚集，并可使动脉内膜斑块面积，内膜斑块面积与中膜面积比值及冠脉病变发生率明显低于高脂组。其作用效果与剂量呈正相关；其作用机理与降低胆固醇，抑制血小板粘附、聚集有关。

In this experiment,the model of experimental atherosclerosis in rabbits was established by feeding the cholesterol contained food for 12 weeks. The effect of Xueguantong (XGT) in inhibiting atherosclerotic formation in rabbits has been studied.It was found that XGT could decrease serum total cholesterol(TC),low density lipoprotein cholesterol (LDL-C),platelet aggregation and platelet adhesion.The aortic atherosclerotic plaque intimal coverage and ratio of atherosclerotic plaque of aortic intimal coverage to aortic medium coverage in XGT groups were significantly smaller than that in the model group(P<0.05).The results showed that XGT could inhibit experimental atherosclerotic formation in rabbits,it might be relevant to that XGT could reduce the TC and inhibit platelet aggregation.