三叉宁对大鼠三叉神经痛的影响

Experimental Study on Effect of Sanchaning in Treating Primary Trigeminal Neuralgia

本研究采用三叉宁对大鼠三叉神经痛模型进行实验性治疗，发现大鼠三叉神经痛样发作的总发作次数、自发反应持续时间、诱发反应阳性时间等指标，三叉宁各组明显低于空白对照组（Ｐ＜０．０１）；三叉宁各组与痛可宁组比较，各项指标差异无显著性意义（Ｐ＞０．０５），提示三叉宁能减轻大鼠三叉神经痛样发作的程度，缩短发作时间，具有明显抑制大鼠三叉神经痛样反应的作用，且与痛可宁作用相当。

Sanchaning is an empirial prescription in treating primary trigeminal neuralgia(PTN).Pills of this prescription have been applied to animal models in an experimental study and their effects were compared with that of distilled water as well as carbamazepine,a common Western medicine for curing PTN.The indexes, including the attack number of PTN of the model animals,the duration of the spontaneous reaction and the positive time of the induced response,showed that Sanchaning differed significantly from distilled water in treating PTN(P<0.01),but slightly differed from that of carbamazepine(p<0.05).The sequential trial has identified that Sanchaning could be used effectively to inhibit PTN and has the same effect as carbamazepine. But further study should be carried out to investigate the mechanism of its function in relieving PTN.