脑梗塞患者同型半胱氨酸的叶酸干预治疗研究

Study on the interventional treatment of cerebral infarction patients with folic acid.

目的观察叶酸干预同型半胱氨酸(HCY)水平的以治疗脑梗塞的临床效果,为临床应用奠定理论基础.方法选择2001年10月～2004年1月住院的长期居住河北地区的急性脑梗塞患者62例,其均符合全国第四届脑血管病会议诊断标准.随机分为两组,其中标准对照(治疗)组32人,仅接受传统危险因素的标准干预治疗;叶酸干预治疗组30人,在标准治疗的基础上加用5mg/d叶酸口服干预治疗.分别检测用药半年前后同型半胱氨酸水平. 结果标准对照组入组时同型半胱氨酸水平为(30.67±14.81)μmol/L,半年后为(34.75±16.17)μmol/L,与用药前相比有显著性升高(P＜0.05),平均升高(4.08±6.06)μmol/L.5mg叶酸干预治疗组用药半年后同型半胱氨酸这(11.77±3.56)μmol/L较用药前(31.32±14.51)μmol/L有显著下降(P＜0.001),平均下降(19.54±13.34)μmol/L. 结论脑梗塞患者的同型半胱氨酸水平可通过补充有效剂量的叶酸进行干预治疗.5mg/d叶酸口服干预治疗可使河北地区脑梗塞患者的同型半胱氨水平明显下降.

Objective To study homocysteine level in patients with cerebral vascular disease. Methods 62 patients with acute cerebral infarction were enrolled in this study admitted from Oct, 2001 to Jan, 2004 and diagnosed as ischemic stroke according to the diagnosis standard published on the collection of National Fourth Cerebral Vascular Disease conference. They were randomized into two groups as following: standard group (32 patients) were only giren accepted conventional therapy; folic acid interventional group (30 patients) were given 5mg/d folic acid intervention in addition to conventional therapy; All the patients were treated for a course of six months. their Hcy levels were measured again in the sixth month. The Hcy level, between pre-and post treatment were compared by paired-sample T test. Results Hey levels between pre-and post treatment. The hcy leve in standard control group was significantly elevated from (30.67±14.81)μmol/L to (34.75±16.17)μmol/L (P>0.05). In 5mg folic acid group, the Hcy level was (11.77±3.56)μmol/L) signifieanty lower than that of pretreatment group((31.32±14.51)μmol/L (P<0. 001). Conclusion The Hcy level of isehemic stroke patients can be intervented by the utilization of effective dose of folic acid. The folic acid dose of 5mg/d is appropriate for reduceing Hcy level in cerebral infaction patierts.