Ⅱ型糖尿病患者不同证型红细胞胰岛素受体缺陷的观察

Relationship between Various Syndrome-Types and Defect of Erythrocyte Insulin Receptors in Non-Insulin Dependent Diabetes Mellitus

用受体微量法测定５７例Ⅱ型糖尿病患者和１８例非糖尿病者红细胞胰岛素受体的变化，以观察Ⅱ型糖尿病患者不同证型红细胞胰岛素受体缺陷的程度。结果表明，Ⅱ型糖尿病患者存在红细胞胰岛素受体缺陷，特点是受体数目减少；Ⅱ型糖尿病患者不同证型红细胞胰岛素受体缺陷的程度不同，阴虚热盛型红细胞胰岛素受体缺陷较轻，气阴两虚型和阴阳两虚型红细胞胰岛素受体缺陷较重。提示Ⅱ型糖尿病不同证型的红细胞胰岛素受体缺陷可随虚损加重而明显。

Fifty-seven patients of non-insulin dependent diabets mellitus(NIDDM) were divided into various groups by Syndrome Differentiation in TCM and 18 cases of non-diabetes mellitus were taken as control.The relationship of Syndrome-types and defect of the erythrocyte insulin receptors were studied with the percentage of specific insulin binding to erythrocyte,number and average affinity of erythrocyte insulin receptors.The results showed:(1) The patients of NIDDM had defect of erythrocyte insulin receptors specified with decreased number of insulin receptors;(2)Mild defect of erythrocyte insulin receptors was found in Syndrome of Yin Deficiency and hyeractivity of Heat, but serious defect in the Syndrome of boch Qi and Yin Deficiency,in the Syndrome of both Yin and Yang Deficiency. Above data suggested that the defect of erythrocyte insulin receptors was correlated with Syndrome-types of patients with NIDDM,the more serious Deficiency Syndrome,the more serious defect of erythrocyte insulin receptors.