黄蜀葵花醇提物治疗糖尿病肾病的临床观察

Clinical Observation on Diabetic Nephropathy Treated with Alcohol Extraction of Abelmoschus mamihot

６８例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）并发糖尿病肾病（ＤＮ）患者随机分为应用黄蜀葵花醇提物加达美康、开博通（观察组），与用达美康加开博通（对照组）８周疗程对比观察，结果观察组尿微量白蛋白（ｍＡｌｂ），尿蛋白（ＵＰ）定量，血、尿微球蛋白（β２－ｍ），尿Ｎ－乙酰－β－氨基葡萄糖苷酶（ＮＡＧ），血过氧化脂质（ＬＰＯ）和血浆超氧阴离子均较治疗前显著降低（Ｐ＜０．０１～０．００１），且显著低于对照组（Ｐ＜０．０５～０．０１），观察组３１例临床期ＤＮ总有效率８３．８７％，明显高于对照组的３１．０３％（Ｐ＜０．０１），提示黄蜀葵花醇提物对ＤＮ可能有消除氧自由基，减轻肾小管间质病变，改善肾功能．降低蛋白尿的作用。

Sixty-eight cases of non-insulin dependent diabetes mellitus(NIDDM)complicated with nephropathy were randomly divided into two groups: treated group,35 cases treated with alcohol extraction of Abelmoschus manihot, Gliclazide and Captopril tablets;control group,33 cases treated with Gliclazide and Captopril tablets, over a period of 8 weeks.The total effective rate in treated and control group were 83.87% and 31.03%(p<0.01),urinary micro-albumin were 31.7mg/L and 76.3mg/L(p<0.05),proteinuria were 0.41g/24h and 0.77g/24h(P<0.01),blood β2-microglobulin were 3317.8ng/ml and 3473.1ng/ml(p<0.05),urinary β2-microglobulin were 367.2ng/ml and 641.5ng/ml(P<0.01),urinary N-acetyl-β-glucosaminidase(NAG) were 26.3u/L and 66.7u/L(P<0.01),plasma lipid peroxide(LPO) were 6.13nmol/L and 8.78 nmol/L(P<0.05),and plasma superoxide anion were 8.36kcpm and 10.42kcpm respectively(P<0.05).It was suggested that Abemoschus manihot alcohol extraction could eliminate oxygen free radicals,alleviate renal tubular-interstitial diseases, improve renal function and reduce proteinuria.