人参多糖对肾病患者外周血单核细胞诱生白细胞介素－2及其受体活性影响

Study on Effect of Polysaccharides of Ginseng on Peripheral Blood Mononuclear Cell Induced Interleukin-2 Production and Activity of Its Receptors in Vitro

通过体外研究证实，人参多糖对健康人和乙肝相关肾炎、肾病综合征和慢性肾功能哀竭患者外周血单核细胞诱生白细胞介素－２及其受体活性具有显著的促进作用，且在所试验的剂量范围内对健康人和三种肾病患者的作用均呈量效依赖性。毒性试验表明人参多糖对血细胞无毒性作用。认为人参作为一种有效生物反应调节剂，应用于临床具有重要的实用和开发价值。

To study the effect of polysaccharides of Ginseng(PSG) on cellular-immunity from healthy subjects and patients of kidney disease,the peripheral blood mononuclear cell(PBMC) induced interleukin-2(IL-2) were assayed in vitro.It was found that the PSG could prommote the PBMC induced IL-2 in the healthy subjects and patients with kidney diseases and was dose-dependent.This study revealed that PSG was worthwhile to be further studied as an approach of biological responsive modifier therepy in treating human immunodeficiency diseases.