蛇床子素和蛇床子总香豆素对肾阳虚小鼠免疫功能的影响

Effects of Osthol and Total-Coumarins from Cnidium Monnieri on Immunological Function in Kidney Yang Deficiency Mice

采用醋酸氢化可的松肾阳虚小鼠模型，观察蛇床子素（ｏｓｔｈｏｌ）和蛇床子总香豆素（ＴＣＲ）对肾阳虚小鼠免疫功能的影响。结果：肾阳虚组与正常对照组比较，腹腔巨噬细胞吞噬百分率和吞噬指数、血清溶血素５０％溶血值、脾淋巴细胞３Ｈ－ＴｄＲ掺入数等指标明显降低（Ｐ＜０．０１）；肾阳虚用ｏｓｔｈｏｌ及ＴＣＲ组与肾阳虚小鼠比较，上述各项指标均有显著提高（Ｐ＜０．０５，＜０．０１）。提示ｏｓｔｈｏｌ和ＴＣＲ可以增强肾阳虚小鼠的免疫功能。

Mice were injected intraperitoneally with hydrocortisone acetate to replicate the animal model of Kidney Yang Deficiency(KYD).Osthol and total-coumarins(TCR)from the fruit of Cnidium monnieri were administered orally to model mice.The effects of osthol and TCR on the immunological function of the KYD mice were observed.The results showed that compare with those in normal mice,the percentage of phagocytosis and the index of macrophage phagocytosis,the level of serum hemolysin and the proliferation of lymphocytes lowered significantly(P<0.01)in model mice.It was shown that administering osthol or TCR could notably(P<0.01)prevent the above-mentioned lowering in model mice,revealing that osthol and TCR could improve the immunological function of KYD mice.