复方银杏叶冲剂治疗慢性乙型肝炎早期纤维化的初步观察

Preliminary Study on Early Fibrosis of Chronic Hepatitis B Treated with Ginkgo Biloba Composita

应用复方银杏叶冲剂治疗８６例慢性乙型迁延性和活动性肝炎早期纤维化患者，疗程３个月，以血清层粘连蛋白（ＬＮ）、血清Ⅲ型前胶原肽（ＰⅢＰ）、超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）及部分光、电镜活检为指标。结果显示治疗后ＰⅢＰ、ＬＮ、ＳＯＤ、ＭＤＡ均有明显下降（Ｐ＜０．０１），病理活检也证实肝纤维化进程获得缓解，从而表明复方银杏叶冲剂对慢性乙型肝炎早期纤维化均有较好疗效。

The purpose of this paper was to study the effect of Ginkgo biloba Composita (GBC) on liver collagen fibrosis. The 86 patients were suffering from chronic persistant and active hepatitis B with early fibrosis confirmed by liver biopsy. Serum pro-collagen-Ⅲ-peptid (PⅢP), laminin (LN), superoxide dismutase (SOD), malonyldialdehyde (MDA) were determined and some patients' biopsies examined with light and electron microscope before and after treatment were observed. By the end of 3 months,the results showed that PⅢP, LN, SOD, MDA were significantly decreased after GBC treatment (P<0.01) and liver fibrosis of patients was partly reabsorbed and had remission. It was suggested that GBC was effective in arresting the development of liver fibrosis of chronic hepatitis.