冠心病患者抗凝系统改变与中医证型关系

Relationship between Anti-Coagulation System Changes of Coronary Heart Disease Patients and Different Syndrome-Type in TCM

本研究应用凝血酶凝胶空斑法、火箭电泳法测定了４６例冠心病患者及４０例健康人的血浆抗凝血酶Ⅲ活性（ＡＴⅢ：Ａ）、抗凝血酶Ⅲ抗原（ＡＴⅢ：Ａｇ）、蛋白Ｃ抗原（ＰＣ：Ａｇ）、总蛋白Ｓ抗原（ＴＰＳ：Ａｇ）、游离蛋白Ｓ抗原（ＦＰＳ：Ａｇ）的水平。结果表明：冠心病气滞型ＰＣ：Ａｇ、ＴＰＳ：Ａｇ显著高于正常对照组（Ｐ均＜０．０５），血瘀型ＡＴⅢ：Ａｇ、ＡＴⅢ：Ａ显著低于正常对照组（Ｐ均＜０．０５），提示ＰＣ：Ａｇ、ＴＰＳ：Ａｇ可作为气滞型的参考指标，ＡＴⅢ：Ａｇ、ＡＴⅢ：Ａ可作为血瘀型的参考指标。

The level of Antithrombin-Ⅲ: antibody (ATⅢ: A), Antithrombin Ⅲ: antigen (ATⅢ: Ag),protein C, antigen (PC : Ag), Total protein S : antigen(TPS : Ag) and Free protein S : antigen (FPS : Ag) were determined in 46 cases of coronary heart disease(CHD) and 40 cases normal control with the thrombin gelplaque technique and the immunoelectrophoresis assay. The results showed: the level of the PC: Ag and TPS: Ag of Qi stagnation type of CHD were significantly higher than those in normal control group (P<0 .05), the level of the AⅢ: Ag, ATⅢ: Ag in blood stasis type of CHD were significantly less than those in control (P<0. 05) . These suggested that the level of PC: Ag and TPS: Ag might be used as referential indices of the Qi stagnation type: the level of ATⅢ: A, ATⅢ: Ag might be used as those of blood stasis type in CHD.