驻春丸对肾阳虚老年人免疫与内分泌功能的影响

Effect of Zhuchun Pill on Immunity and Endocrine Function of Elderly with Kidney-Yang Deficiency

将４５例肾阳虚男性老年人随机分为驻春丸组和淀粉胶囊安慰组，单盲法，疗程为３个月。结果：驻春丸可使肾阳虚老年人主要临床症状明显改善，与对照组比较，Ｐ＜０．０ｌ；氚胸腺嘧啶掺入法淋巴细胞转化率、血清Ｃ３、ＩｇＡ，ＩｇＤ，ＩｇＧ与ＩｇＭ含量增加（Ｐ＜０．０１）；血浆肾上腺皮质激素、睾酮、环磷酸腺苷含量上升（Ｐ均＜０．０１）；血清超氧化物歧化酶（ＳＯＤ）含量升高而血浆过氧化脂质（ＬＰＯ）含量下降（Ｐ＜０．０１）。对照组无此明显变化。提示驻春丸改善肾阳虚证是通过调节机体免疫、内分泌功能和清除自由基的机制实现的。

After randomly dividing 45 elderly males with Kidney-Yang Deficiency into Zhuchun Pill (ZCP) group and placebo (starch capsule) group by single blind method, and treating them for 3 months,we found that ZCP could greatly improve the main symptoms of Kidney-Yang Deficiency, P<0. 01 by comparison with control group: the 3H-TdR lymphocyte transformation (3H-TdR LCT) rate,level of serum C3,IgA, IgD, IgG & IgM went up (p<0.01); contents of plasma adrenocortical hormone (ACTH) ,testosterone (T) and cyclic adenosine monophosphate (cAMP) increased (P< 0.01 ￣0.001) : the level of superoxide dismutase (SOD) in serum also increased while lipid peroxide (LPO) in plasma decreased (P<0. 01). But for control group, there were no remarkable changes after treatment,so it revealed that the improvement of Kidney-Yang Deficiency by ZCP is realized through regtilating the organism's immunity and endocrine function as well asthrough scavenging the free radical agents.