右归饮对皮质酮大鼠下丘脑单胺类递质含量以及体重饮食摄水的影响

Effect of Yougui Yin on the Content of Monoaminic Transmitters and Body Weight,Food and Fluid intake in Corticosterone-Rats

本研究观察大鼠在每日注射皮质酮（１０ｍｇ／ｋｇ皮下注射共１４天）状态下，下丘脑单胺类递质含量、每日体重、饮食、摄水的变化，以及右归饮对这些变化的影响。结果表明：皮质酮大鼠下丘脑去甲肾上腺素、３，４二羟基苯乙酸、多巴胺、５－羟基吲哚乙酸、５－羟色胺等单胺类递质含量明显升高，体重增长严重受抑，每日饮食与摄水量显著减少；加用右归饮（１０ｇ／ｋｇ灌胃共１４天）后能有效改善皮质酮大鼠的上述各项指标。提示：外源性糖皮质激素在抑制下丘脑—垂体—肾上腺轴（ＨＰＡ）时可能激活中枢单胶类递质的合成与代谢和抑制体重增长，减少每日饮食摄水量；右归饮在改善皮质酮大鼠ＨＰＡ轴抑制程度的同时，抑制其中枢单胺类递质的激活，保护下丘脑对饮食摄水的正常调节。

Great attention has been paid to the relationship between the central monoaminic transmitters and the hypothalamus-pituitary-adrenal(HPA) axis recently.This paper reported the content of hypothalamic monoaminic transmitters of rats,which were injected with corticosterone 10 mg/kg subcutaneously for 14 days.The body weight as well as volume of food and fluid intake were measured in the same period.Effect of Yougui Yin(YGY,administrated by gastrogavage) on he cortico-inhibited rats was also observed.Results showed that the contents of hypothalamic monoaminic transmitters such as norepinephrine,Dopamine,3,4-Dihydroxyphenylalanine,serotonin,and 5-hydroxyindole acetic acid of the rats increased obviously,while the body weight,volume of food and fluid intake decreased significantly day by day.The YGY could improve the abovementioned indexes significantly.It suggested that:(1)The synthesis and metabolism of the central monoaminic transmitters of rats activated when the HPA axis was inhibited by exogenous glucocorticoid,their body weight lowered,and the Volume of food and fluid intake decreased.(2) YGY could improve the inhibited HPA axis,and inhibit the activated central monoaminic transmitters as well as protect the normal regulating function of hypothalamus on food and fluid intake.