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伽玛刀短期剂量分割治疗脑干胶质瘤的临床研究 被引量:2

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摘要 目的探讨改变剂量给予方式时伽玛刀治疗脑干胶质瘤的临床疗效。方法应用OUR-RGS/G型旋转式伽玛刀治疗脑干胶质瘤30例,选择治疗条件相近的每2例临床病例配对,共15对,分两组。一组采用常规一次性剂量照射,肿瘤边缘剂量约12.0Gy,等剂量曲线50%~60%;另一组采用短期分次(2次)治疗,每次边缘剂量约6.0Gy,等剂量曲线50%~60%。结果全部病例随访时间为3个月~24个月;单次治疗组好转4例(26.7%),稳定4例(26.7%),恶化4例(26.7%),死亡3例(20%),有效率为53.3%;分次治疗组好转8例(53.3%),稳定3例(20%),恶化2例(13.3%),死亡2例(13.3%),有效率73.3%。治疗后同期影像学复查显示瘤周水肿反应单次组较分次组明显。说明短期剂量分割治疗能提高疗效,与单次组比较具有显著性差异(P<0.05)。结论伽玛刀短期剂量分割治疗脑干胶质瘤疗效优于单次大剂量治疗,且术后不良反应较轻。
出处 《临床医药实践》 2005年第7期489-491,共3页 Proceeding of Clinical Medicine
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同被引文献10

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