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死亡受体在间变性星形细胞瘤中的表达研究

Expression of DR in Human Anaplastic Astrocytoma
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摘要 目的研究TRAIL的死亡受体(deathreceptor,DR)DR4和DR5在间变性星形细胞瘤中的表达,探讨其临床意义。方法采用免疫组化方法检测34例间变性星形细胞瘤及25例正常脑组织中TRAILR的表达。结果34例间变性星形细胞瘤均大量表达死亡受体(deathreceptor,DR)DR4和DR5,而25例正常脑组织中11例(44·0%)表达DR4,9例(36·0%)表达DR5。间变性星形细胞瘤组织中DR的高表达明显不同于正常脑组织中DR的低表达,两者间差异有显著性(P<0·01)。结论间变性星形细胞瘤中普遍存在DR的高表达,这可能为间变性星形细胞瘤的凋亡诱导治疗提供新的靶点和新的策略。 Objective To investigate the expression and significance of DR4 and DR5 in human anaplastic astrocytoma.Methods The expression of DR was determined by immunohistochemistry in 4 samples with anaplastic astrocytoma and 25 samples with normal brain tissues. Results With low expression in partial normal brain cells ,DR was expressed highly in all anaplastic astrocytoma samples .High DR expression in anaplastic astrocytoma tissues differed from low DR expression in normal brain tissues(P<0.01).Conclusions High DR expression is prevalent in anaplastic astrocytoma tissues. This may contribute to the apoptosis-inducing therapy of anaplastic astrocytoma.
作者 赵忠伟 曹风雨 李晟磊 王新军 贺付成 张云汉
机构地区 河南省肿瘤病理重点实验室 郑州铁路局中心医院神经外科
出处 《河南肿瘤学杂志》 2005年第4期229-230,共2页 Henan Journal of Oncology
基金 国家"十五""211工程"重点学科建设项目 教重办(2002)第2号
关键词 间变性星形细胞瘤 TRAIL 细胞凋亡 anaplastic astrocytoma TRAIL apoptosis
分类号 R730.26 [医药卫生—肿瘤]
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参考文献7

  • 1Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis[J]. Immunity,1995,3(6) :673 - 682.
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二级参考文献7

  • 1[1]Wiley SR,Schooley K,Smolak PJ et al.Identification and characterization of a new member of the TNF family that induces apoptosis.Immunity,1995,3:673
  • 2[2]Pitti RM,Marsters SA,Ruppert S et al.Induction of apoptosis by Apo-2ligand, a new member of the tumor necrosis factor cytokine family.J Biol Chem,1996,271(22):12687
  • 3[3]Griffith TS,Chin WA,Jackson GC et al. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J Immunol,1998,161:2833
  • 4[4]Pan G,Ni J,Wei YF et al.An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science(Wash.DC),1997,277:815
  • 5[5]Sheridan JP,Marsters SA,Pitti RM et al.Control ofTRAIL-induced apoptosis by a family of signaling and decoy receptors.Science(Wash.DC),1997,277:818
  • 6[6]Frank S,Kohler U,Schackert G et al. Expression ofTRAIL and its receptors in human brain tumors.Biochem Biophys Res Commun,1999,257(2):454
  • 7[7]Jo M,Kim TH,Seol DW,Esplen JE et al.Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related qpoptosis-inducing ligand.Nat Med,2000,6(5):564

共引文献10

河南肿瘤学杂志
2005年 第4期

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