胃癌组织中肝素酶mRNA的表达

Expression of HPA mRNA in Gastric Carcinoma

目的探讨肝素酶mRNA在胃腺癌组织中的表达情况及其与临床病理学参数的关系。方法采用半定量RT-PCR检测36例胃腺癌组织及11例正常胃黏膜组织中肝素酶mRNA表达水平。结果HPAmRNA阳性表达与胃癌的浆膜浸润和淋巴结转移成正相关(P<0·05),与胃癌患者的性别、年龄、大体类型及肿瘤发生部位无关(P>0·05)。结论HPA可能是胃癌侵袭转移的重要生物学标记,并可作为判断胃癌预后的指标之一。

Objective To explore the relationships between HPA mRNA expression in gastric carcinomas and the clinic pathological features. Methods RT-PCR was performed to detect and semi-quantitate the expression of HPA mRNA in 6 gastric carcinoma tissues.Results The expression level of HPA mRNA was positively related to serosal invasion and lymph node metastasis(P<0.05), and had no association with gender, age, Borrmann gross type and tumor location (P>0.05). Conclusions HPA might be a novel biomarker for invasion and metastasis of gastric carcinoma, and used to predict the prognosis of gastric carcinoma.