大肠癌组织中Survivin的表达与微血管密度的关系

Relationship of Expression of Survivin and MVD in Colorectal Carcinoma

目的探讨Survivin在大肠癌发病机制中的作用与微血管密度(MVD)的关系及其临床意义。方法对48例大肠癌组织用免疫组织化学技术分别检测Survivin的表达及MVD。结果大肠癌组织Survivin表达阳性率为52.1%(25/48),癌旁正常组织均无表达。Survivin表达与大肠癌分化程度、淋巴结转移明显相关(P<0.05,P<0.01)。MVD表达与大肠癌淋巴结转移显著相关(P<0.01)。Survivin与MVD的表达具有一致性,两者同时表达的大肠癌更容易发生淋巴结转移。结论Survivin基因表达与大肠癌生物学行为有密切关系,检测Survivin的表达水平对于大肠癌的诊断、恶性程度及预后的判断均有一定价值。

Objective To investigate the role of Survivin gene in colorectal carcinoma and connection with microvessel density(MVD) and its clinical significance.Methods The expression of Survivin and MVD was detected by immunohistochemical method in 48 cases with colorectal carcinoma.Results Survivin expression was positive in 25 cases(52.1%), while no expression was detected in adjacent normal tissues. The expression of Survivin significantly correlated with histological differentiation and lymph node metastasis (P<0.05,P<0.01). MVD was higher in the cases lymph node metastasis than those without (P<0.01). The colorectal carcinoma which expressed both the Survivin and MVD were more inclined to occur lymph node metastasis.Conclusion The expression of Survivin and MVD has a significant correlation to the biological behavior in colorectal carcinoma. Detection of Survivin expression may be valuable for diagnosing colorectal carcinoma, and evaluating malignancy extent and prognosis.